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Your answer: Option A · Correct: Option B

Explanation

PFK-1 is the rate-limiting and committed step enzyme of glycolysis, catalysing the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate.

It is allosterically inhibited by ATP (high-energy signal) and activated by AMP, ADP, and fructose-2,6-bisphosphate. This makes it the primary regulatory node responding to cellular energy status. Citrate also inhibits PFK-1, linking glycolysis to oxidative phosphorylation.

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Your answer: Option A · Correct: Option B

Explanation

PFK-1 is the rate-limiting and committed step enzyme of glycolysis, catalysing the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. It is allosterically inhibited by ATP (high-energy signal) and activated by AMP, ADP, and fructose-2,6-bisphosphate. This makes it the primary regulatory node responding to cellular energy status. Citrate also inhibits PFK-1, linking glycolysis to oxidative phosphorylation.

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